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There are two types of melanin, eumelanin and pheomelanin 1,2

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Remarkably, at least in blood-borne macrophages, the ability of oxysterols to downregulate inflammasome activity, and thus IL-1 production, seems to rely on its inhibitory effect on cholesterol synthesis [27]

3 Although no studies have prospectively stratified patients by baseline A1C in evaluation of the A1C-lowering efficacy of a DPP-4 inhibitor or SGLT2 inhibitor, post-hoc subgroup analyses have shown that the efficacy of SGLT2 inhibitors is greater than that of DPP-4 inhibitors among patients with higher baseline A1C ( 8-8.5%), while patients with baseline A1C at the lower end of the spectrum ( 30 mL/min and clinical CV disease according to Diabetes Canada